mes-4 Antibody

Datasheet

Code	CSB-PA882047XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans mes-4 Polyclonal antibody

Uniprot No.

Q9NH52

Target Names

mes-4

Alternative Names

mes-4 antibody; Y2H9A.1 antibody; Histone-lysine N-methyltransferase mes-4 antibody; EC 2.1.1.357 antibody; Maternal-effect sterile protein 4 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans mes-4 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to RNAi. May regulate the expression of genes required for vulval development.

Gene References into Functions

MES-4 transmits the memory of gene expression in the parental germ line to offspring. PMID: 20824077
MES-4 has histone H3 methyltransferase (HMT) activity in vitro, and is required for histone H3K36 dimethylation in mitotic and early meiotic germline nuclei and early embryos. PMID: 16968818

Subcellular Location

Nucleus. Chromosome. Note=Specifically associated with the autosomes and with the distal tip of chromosome X. Colocalizes with methylated 'Lys-4' of histone H3.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily

Tissue Specificity

In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells.

Database Links

KEGG: cel:CELE_Y2H9A.1

STRING: 6239.Y2H9A.1.2

UniGene: Cel.6195

Promotions

20% OFF All In-Stock Recombinant Antibodies

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mes-4 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background