mett-10 Antibody

Datasheet

Code	CSB-PA600995XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans mett-10 Polyclonal antibody

Uniprot No.

Q09357

Target Names

mett-10

Alternative Names

mett-10 antibody; ZK1128.2U6 small nuclear RNA antibody; adenine-(43)-N(6))-methyltransferase antibody; EC 2.1.1.346 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans mett-10 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence. Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo.

Gene References into Functions

METT-10 functions to inhibit germ-cell proliferative fate, despite promoting mitotic cell cycle progression of those germ cells that do proliferate, separates the specification of proliferative fate from its execution. PMID: 19596901

Subcellular Location

Nucleus.

Protein Families

Methyltransferase superfamily, METTL16/RlmF family

Tissue Specificity

Expressed in the intestine, vulva, and cells of the somatic gonad including distal tip cells, gonadal sheath cells and spermatheca.

Database Links

KEGG: cel:CELE_ZK1128.2

STRING: 6239.ZK1128.2a

UniGene: Cel.9495

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mett-10 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background