Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MGM1 Polyclonal antibody

Uniprot No.

P32266

Target Names

MGM1

Alternative Names

MGM1; MDM17; YOR211C; YOR50-1; Dynamin-like GTPase MGM1, mitochondrial; Mitochondrial division and morphology protein 17; Mitochondrial genome maintenance protein 1

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MGM1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane.

Gene References into Functions

Mgm1 membrane interactions impose a mechanical force on the membrane to overcome the hydrophilic repulsion of the phospholipid head groups and initiate the fusion reaction. PMID: 25784211
Psd1 promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of Mgm1. PMID: 23045528
Mechanistic details of the two known in vivo functions of Mgm1, membrane fusion and cristae maintenance. PMID: 22977249
Absence of mitochondrial fusion in the Deltamgm1 mutant leads to a striking reduction of both replicative and chronological lifespan. PMID: 21912203
Data show that charged residues in the regions flanking the first segment in Mgm1p critically affect the ratio between the two isoforms, providing new insight of charged residues in the insertion of proteins into the mitochondrial inner membrane. PMID: 21457713
Trans Mgm1 interactions on opposing inner membranes function similarly to tether and fuse inner membranes as well as maintain crista structures and propose a model for how the mitochondrial dynamins function to facilitate fusion. PMID: 17055438
Mgm1 promotes the fusion of opposing mitochondrial inner membranes PMID: 19703904
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. PMID: 19752025

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Subcellular Location

[Dynamin-like GTPase MGM1 large isoform]: Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side. Mitochondrion intermembrane space.; [Dynamin-like GTPase MGM1 small isoform]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Database Links

KEGG: sce:YOR211C

STRING: 4932.YOR211C

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MGM1 Antibody

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