mapk-15 Antibody

Code CSB-PA606129XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans mapk-15 Polyclonal antibody
Uniprot No.
Target Names
mapk-15
Alternative Names
mapk-15 antibody; swip-13 antibody; C05D10.2Mitogen-activated protein kinase 15 antibody; EC 2.7.11.24 antibody; Swimming-induced paralysis protein 13 antibody; SWIP-13 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans mapk-15 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance. Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, probably by restricting expansion of the subcellular sensory compartment at the dendrite ending.
Gene References into Functions
  1. Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species. PMID: 29021280
  2. MAPK-15 is a ciliary protein required for PKD-2 localization and male mating behavior in Caenorhabditis elegans PMID: 28745435
Subcellular Location
Cell projection, dendrite.; [Isoform a]: Perikaryon. Cell projection, dendrite. Cell projection, cilium. Cell projection, cilium membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cell junction.; [Isoform c]: Perikaryon. Cell projection, dendrite. Cell projection, cilium. Cell projection, cilium membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cell junction.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Tissue Specificity
Expressed in the URX neuron and in many other head sensory neurons. Isoform a: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons. Isoform c: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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