mle Antibody

1. We have employed a systems biology approach (microarray) to investigate the global aneuploid effect of the maleless (mle) mutation that disrupts the binding of male specific lethal (MSL) proteins that function in dosage compensation. PMID: 27456781
2. MLE specifically targets hairpin RNAs at their site of transcription. The association of MLE at these sites is independent of sequence and chromosome location PMID: 26752049
3. The Drosophila Helicase MLE is Implicated in Functions Distinct From its Role in Dosage Compensation PMID: 25776889
4. Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. PMID: 26545078
5. UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. PMID: 25158899
6. Study reports that mle (napts) mutant flies exhibit developmental lethality, decreased fecundity and increased neurodegeneration. PMID: 22513411
7. Data suggest that MLE can stimulate the transcription activity of rox2 and that MLE associates with rox2 through direct interaction with a newly identified 54-bp repeat, Prox. PMID: 15358781
8. Zn72D is required for productive splicing of the transcript for the MSL protein Maleless, explaining the dosage compensation defect. PMID: 17923683
9. the ATPase activity is sufficient for MLE's role in transcriptional enhancement, while the helicase activity is necessary for the spreading of the complex along the X chromosome PMID: 18039854
10. A maleless structure-function analysis clarified the domain requirements for RNA interaction, helicase activity and localization to the X chromosomal territory. PMID: 18086708
11. the minimal transactivation domain of MLE mediates the expression of MLE target genes through recruitment of Pol II PMID: 18360693

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KEGG: dme:Dmel_CG11680

STRING: 7227.FBpp0085367

UniGene: Dm.2901