MPC1 Antibody

Code CSB-PA345656XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MPC1 Polyclonal antibody
Uniprot No.
Target Names
MPC1
Alternative Names
MPC1; FMP37; YGL080W; Mitochondrial pyruvate carrier 1; MPC1; Protein FMP37
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MPC1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mediates the uptake of pyruvate into mitochondria.
Gene References into Functions
  1. while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes PMID: 25672363
  2. Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; loss of Mpc1 results in defective mitochondrial pyruvate uptake; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier PMID: 22628558
  3. study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake PMID: 22628554
Subcellular Location
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
Database Links

KEGG: sce:YGL080W

STRING: 4932.YGL080W

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