Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MSI1 Polyclonal antibody

Uniprot No.

O22467

Target Names

MSI1

Alternative Names

MSI1 antibody; At5g58230 antibody; MCK7.10 antibody; Histone-binding protein MSI1 antibody; CAF-1 p48 homolog antibody; Chromatin assembly factor 1 subunit MSI1 antibody; CAF-1 subunit MSI1 antibody; Protein MULTICOPY SUPPRESSOR OF IRA 1 antibody; AtMSI1 antibody; Protein medicis antibody; WD-40 repeat-containing protein MSI1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana MSI1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repressive state of homeotic genes throughout development. Required for several aspects of plant development including normal leaf expansion, correct development of flowers, normal endosperm development, repression of parthenogenetic seed development and repression of floral homeotic genes in leaf tissue. Also required for the recruitment of chromosomal DNA into heterochromatic chromocenters. Also involved in regulation of imprinted genes. Acts together with RBR1 to repress the expression of MET1 during female gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA.

Gene References into Functions

MSI1 is a novel gene which regulates flowering. PMID: 16554362
These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development. PMID: 17021044
Data suggest that the Polycomb group protein MSI1 functions in the female gametophyte to determine seed development in plants. PMID: 17855429
Rb-dependent activation is mediated by direct transcriptional repression of MET1 during female gametogenesis. PMID: 18700816

Subcellular Location

Nucleus.

Protein Families

WD repeat RBAP46/RBAP48/MSI1 family

Tissue Specificity

Ubiquitously expressed. Strongly expressed in floral buds and flowers, the female gametophyte and the sporophytic tissue of the ovules. Also strongly expressed in developing embryos following fertilization.

Database Links

KEGG: ath:AT5G58230

STRING: 3702.AT5G58230.1

UniGene: At.49185

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MSI1 Antibody

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