MSN2 Antibody

1. Under non-stress conditions, stress-responsive transcriptional activator Msn2 is more abundant in the nucleus of the high tolerance spore clone. High tolerance to oxidative stress in this spore clone results from a high expression of reactive oxygen species-degrading enzymes by the abundant accumulation of Msn2 in the nucleus. PMID: 29607878
2. In this mutant lacking the Snf1-mediated positive feedback loop, Msn2 responds similarly to glucose limitation and osmotic stress, and its pulsatile translocation is largely abrogated. PMID: 28637875
3. Information transduction through amplitude and frequency regulation of Msn2 is limited to error-free transduction of signal identity, but not signal intensity information. PMID: 25985085
4. the environmental stress response in the yeast S. cerevisiae constitutes a system where gene activation is linearly commensurate with the cell's perception of environmental stress as encoded by the level of active Msn2. PMID: 24210615
5. A dynamic interplay between nucleosomes and Msn2 regulates gene expression in yeast stress response. PMID: 24598258
6. Data indicate that Msn2-GFP resides in the nucleus under unstressed conditions, but 80-90% accumulates in the nucleus after a severe stress. PMID: 23615444
7. AUthors identified new functional motifs in the Msn2 transcriptional-activating domain. PMID: 22505609
8. Msn2 acted as a tunable signal processor that could track, filter, or integrate signals in an input-dependent manner; this tunable signal processing appears to originate from dual regulation of both nuclear import and export by phosphorylation PMID: 23349292
9. Data show that the identities and intensities of different stresses are transmitted by modulation of the amplitude, duration or frequency of nuclear translocation of the general stress response transcription factor Msn2. PMID: 22179789
10. PP2A and the Tor kinase pathway transduce stress and nitrogen starvation signals to Msn2p. PMID: 15470255
11. increased degradation of nuclear Msn2 might be necessary to adapt cells to low PKA conditions after the diauxic shift or to allow growth under chronic stress conditions PMID: 15502160
12. The general stress responses of yeast genes are activated by Msn2. PMID: 15545648
13. Stress response transcription factors Msn2p/4p are repressed by protein kinase A. PMID: 15545649
14. localization determinants present in the N-terminal half of Msn2p are insensitive to variations in the intracellular cAMP concentrations PMID: 16489456
15. Genes regulated by Plc1p do not correlate with gene sets regulated by Swi/Snf or RSC chromatin remodeling complexes but show correlation with genes controlled by Msn2p. PMID: 18375619
16. stochastic version of the model for periodic nucleocytoplasmic shuttling of Msn2 coupled to oscillations in the cAMP-PKA pathway PMID: 18492651
17. In this review, Msn2 and Msn4 regulation during heat stress response is discussed. PMID: 19435282

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KEGG: sce:YMR037C

STRING: 4932.YMR037C