MXR1 Antibody

Code CSB-PA331115XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MXR1 Polyclonal antibody
Uniprot No.
Target Names
MXR1
Alternative Names
MXR1 antibody; YER042W antibody; Peptide methionine sulfoxide reductase antibody; EC 1.8.4.11 antibody; Peptide-methionine antibody; S)-S-oxide reductase antibody; Peptide Met(O) reductase antibody; Protein-methionine-S-oxide reductase antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MXR1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product.
Gene References into Functions
  1. the plasticity of the Trx binding site on Mxr1 provides structural insights into the recognition of diverse substrates by a universal catalytic motif of Trx. PMID: 21345799
  2. under normal growth conditions thioredoxin 1 is essential for msrA transcription and activity PMID: 16631529
  3. interacts with glutathione peroxidase Gpx3; Gpx3 functions as a redox-dependent exquisite regulator of the protein repair activity of Mxr1 PMID: 16808898
  4. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. PMID: 19049972
  5. MSRA and MSRB helps to preserve the function of cellular FeS clusters from oxidative inactivation. PMID: 19202110

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Protein Families
MsrA Met sulfoxide reductase family
Database Links

KEGG: sce:YER042W

STRING: 4932.YER042W

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