mth Antibody

1. this study identifies Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling. PMID: 27708106
2. Methuselah gene mutation is associated with tolerance of dichlorvos exposure in Drosophila melanogaster. PMID: 25746179
3. mth has a statistically significant advantage in maintaining continuous flight over control flies at age 10 days, but not during middle and late life. mth flies had lower levels of locomotor activity relative to controls at ages 50 and 60 days. PMID: 23913251
4. While our data support a role for mth variation being under natural selection, we found no link to naturally occurring variation in lifespan and ageing in Australian populations of D. melanogaster. PMID: 23802551
5. Identified two additional activators of Mth signaling: Drosophila Sex Peptide (SP) and a novel peptide (Serendipitous Peptide Activator of Mth, SPAM). PMID: 19672878
6. where the life span is extended, there is an offsetting effect on reproductive output, suggesting that the methuselah mutation induces trade-off effects and is not a direct, mechanistic regulator of the aging process. PMID: 16677788
7. Mth gene delays chronological aging but also enhances sensorimotor abilities critical to survival during early and middle, but not late life. PMID: 17534708
8. allelic variation at mth contributes to observed differences in lifespan and correlated phenotypes in natural populations of Drosophila PMID: 18414670

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KEGG: dme:Dmel_CG6936

STRING: 7227.FBpp0072470

UniGene: Dm.4379