Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MYB46 Polyclonal antibody

Uniprot No.

Q9LXV2

Target Names

MYB46

Alternative Names

MYB46 antibody; At5g12870 antibody; T24H18.40 antibody; Transcription factor MYB46 antibody; Myb-related protein 46 antibody; AtMYB46 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana MYB46 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Transcription activator. Involved in the regulation of secondary wall biosynthesis in fibers and vessels. Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis-regulatory element of CSLA9 promoter. Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1. Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wall formation in fibers and vessels. Transcription activator that binds to the DNA consensus sequence 5'-ACC[AT]A[AC][TC]-3', designated as the secondary wall MYB-responsive element (SMRE). Regulates directly numerous transcription factors and a number of genes involved in secondary wall biosynthesis that contain SMRE elements in their promoters. Is an obligate component of the transcriptional regulatory complex toward the commitment of secondary wall cellulose synthesis. Is required for functional expression of the three secondary wall CESA genes, CESA4, CESA7 and CESA8.

Gene References into Functions

directly regulates all three secondary wall-associated cellulose synthase genes PMID: 26011122
MYB46 is a unique transcription factor in that it directly regulates the biosynthesis genes for all of the three major components of the secondary wall as well as the transcription factors in the biosynthesis pathway. PMID: 24984711
MYB46 functions as a central and direct regulator of the genes involved in the biosynthesis of all three major secondary wall components. PMID: 24879533
Data conclude that MYB46 is an obligate component of the transcriptional regulatory complex toward the commitment of secondary wall cellulose synthesis in Arabidopsis. PMID: 23726771
MYB46 mediated the transcriptional regulation of secondary wall biosynthesis. PMID: 22914575
MYB46 activates the secondary wall MYB-responsive element sites in the promoters of MYB46 direct targets. MYB46 and MYB83 directly activate a set of downstream transcription factors. PMID: 22197883
MYB46 recognizes a cis-acting regulatory motif M46RE PMID: 22271306
The observed coordinated down-regulation of CesA genes is more pronounced, and occurs earlier, in myb46 mutant plants. PMID: 21617373
MYB46 gene expression does not change following interaction with pathogens. myb46 mutants have enhanced disease resistance to B. cinerea. PMID: 21282403
MYB46 activates the expression of selected transcription factors and genes involved in the biosynthesis of secondary wall components. PMID: 19674407
These results demonstrate that MYB46 is a direct target of SND1 and is another key player in the transcriptional network involved in the regulation of secondary wall biosynthesis in Arabidopsis. PMID: 17890373

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed at low levels in stems and siliques, specifically in xylem.

Database Links

KEGG: ath:AT5G12870

STRING: 3702.AT5G12870.1

UniGene: At.5283

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MYB46 Antibody

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