NDC80 Antibody

1. Thus, expression of a 5' extended mRNA isoform causes transcriptional interference at the downstream promoter of NDC80. The authors demonstrate that this is an effective mechanism to promote dynamic changes in gene expression during cell differentiation. PMID: 28906248
2. The authors discovered that in budding yeast, kinetochore inactivation during meiosis occurs by reducing the abundance of a limiting subunit, Ndc80. PMID: 28906249
3. Ndc80 helical hairpin, microtubule-binding and the tetramerization domains are essential for Ndc80 function. PMID: 23833183
4. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential.Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint. PMID: 19822728
5. data on the four-protein Ndc80 complex suggests that the Spc24p/Spc25p end of the rod faces the centromere and the Ndc80p/Nuf2p end faces a spindle microtubule PMID: 15809444
6. Results suggest that the conformational kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore. PMID: 18793650
7. Findings demonstrate how an ensemble of Ndc80 complexes may provide the combination of plasticity and strength that allows kinetochores to maintain load-bearing tip attachments during both microtubule assembly and disassembly. PMID: 19269365

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KEGG: sce:YIL144W

STRING: 4932.YIL144W