NDF1 Antibody

Code CSB-PA015725XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) neurod1 Polyclonal antibody
Uniprot No. O42202
Target Names neurod1
Alternative Names neurod1 antibody; neurod antibody; nrdNeurogenic differentiation factor 1 antibody; NeuroD antibody; NeuroD1 antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) NDF1 protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
Gene References into Functions
  1. during embryonic development, NeuroD governs photoreceptor genesis via non-cell-autonomous mechanisms and that, during photoreceptor development and regeneration, Notch signaling is a mechanistic link between NeuroD and cell cycle exit. PMID: 26580854
  2. differential levels of Neurod are required to generate endocrine pancreas subtypes from precursors during both embryonic and larval stages PMID: 25797153
  3. Transcription factor neuroD, involved in retinogenesis, is co-opted by the circadian clock following photoreceptor differentiation. PMID: 24924194
  4. Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet. PMID: 19759004
  5. The control of endocrine cell fate is instead fulfilled by two basic helix-loop-helix factors, Ascl1b and Neurod1 and NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates. PMID: 23835295
  6. the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of posterior lateral line neurons PMID: 23303935
  7. BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. PMID: 12204253
  8. in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1 PMID: 16678150
  9. Coexpressed with cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors. In zebrafish retina, similar genetic cascades may regulate photoreceptor genesis and maturation. PMID: 17206615
  10. NeuroD plays a fundamental role in photoreceptor genesis by regulating mechanisms that promote rod and cone progenitors to withdraw from the cell cycle. PMID: 19121642

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Subcellular Location Cytoplasm, Nucleus
Tissue Specificity In the embryo, expressed broadly in a subset of primary neurons in the brain and spinal cord. At 28 hours post-fertilization (hpf), regions of expression include telencephalon, olfactory placode, epiphysis, cranial ganglia, acoustic ganglia, Rohon-Beard m
Database Links

KEGG: dre:30169

STRING: 7955.ENSDARP00000026490

UniGene: Dr.75801

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