Recombinant Danio rerio Neurogenic differentiation factor 1(neurod1)

Code CSB-YP015725DIL
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Source Yeast
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Code CSB-EP015725DIL
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Source E.coli
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Code CSB-EP015725DIL-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015725DIL
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Source Baculovirus
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Code CSB-MP015725DIL
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names neurod1
Uniprot No. O42202
Alternative Names neurod1; neurod; nrdNeurogenic differentiation factor 1; NeuroD; NeuroD1
Species Danio rerio (Zebrafish) (Brachydanio rerio)
Expression Region 1-350
Target Protein Sequence MTKSYSEESM MLESQSSSNW TDKCHSSSQD ERDVDKTSEP MLNDMEDDDD AGLNRLEDED DEEEEEEEED GDDTKPKRRG PKKKKMTKAR MQRFKMRRMK ANARERNRMH GLNDALESLR KVVPCYSKTQ KLSKIETLRL AKNYIWALSE ILRSGKSPDL MSFVQALCKG LSQPTTNLVA GCLQLNPRTF LPEQSQEMPP HMQTASASFS ALPYSYQTPG LPSPPYGTMD SSHIFHVKPH AYGSALEPFF DTTLTDCTSP SFDGPLSPPL SVNGNFSFKH EPSSEFEKNY AFTMHYQAAG LAGAQGHAAS LYAGSTQRCD IPMENIMSYD GHSHHERVMN AQLNAIFHDS
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
Gene References into Functions
  1. during embryonic development, NeuroD governs photoreceptor genesis via non-cell-autonomous mechanisms and that, during photoreceptor development and regeneration, Notch signaling is a mechanistic link between NeuroD and cell cycle exit. PMID: 26580854
  2. differential levels of Neurod are required to generate endocrine pancreas subtypes from precursors during both embryonic and larval stages PMID: 25797153
  3. Transcription factor neuroD, involved in retinogenesis, is co-opted by the circadian clock following photoreceptor differentiation. PMID: 24924194
  4. Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet. PMID: 19759004
  5. The control of endocrine cell fate is instead fulfilled by two basic helix-loop-helix factors, Ascl1b and Neurod1 and NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates. PMID: 23835295
  6. the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of posterior lateral line neurons PMID: 23303935
  7. BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. PMID: 12204253
  8. in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1 PMID: 16678150
  9. Coexpressed with cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors. In zebrafish retina, similar genetic cascades may regulate photoreceptor genesis and maturation. PMID: 17206615
  10. NeuroD plays a fundamental role in photoreceptor genesis by regulating mechanisms that promote rod and cone progenitors to withdraw from the cell cycle. PMID: 19121642

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Subcellular Location Cytoplasm, Nucleus
Tissue Specificity In the embryo, expressed broadly in a subset of primary neurons in the brain and spinal cord. At 28 hours post-fertilization (hpf), regions of expression include telencephalon, olfactory placode, epiphysis, cranial ganglia, acoustic ganglia, Rohon-Beard m
Database Links

KEGG: dre:30169

STRING: 7955.ENSDARP00000026490

UniGene: Dr.75801

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