NDI1 Antibody

1. Ubiquinone binding site of yeast NADH dehydrogenase Ndi1 has been described. PMID: 29402945
2. Ndi1 associations took place with complexes III and IV suggest the formation of respirasome-like structures. PMID: 26173916
3. Ndi1 assimilates electrons to the electron transport chain and initiates the respiration process to make ATP, whereas under stresses, it cleaves the toxicity-sequestering N-terminal cap, is released from the mitochondria, and becomes a cell killer. PMID: 22993213
4. The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates PMID: 22949654
5. Our data indicate a central role for Complex I dysfunction in pink1-associated defects, and our genetic analyses with heterologous ETC enzymes PMID: 22242018
6. Perfusion of TAT-Ndi1 before 30 min no-flow ischemia and up to 2 hr reperfusion suppressed ROS production and preserved ATP stores. Importantly, TAT-Ndi1 infused before ischemia reduced infarct size by 62%. PMID: 21339825
7. the Ndi1 reaction proceeds through a ternary complex (not a ping-pong) mechanism. The bound UQ keeps oxygen away from the reduced flavin. PMID: 21220430
8. Yeast NDI1 expression in Drosophila mitigated the aging associated decline in respiratory capacity and the accompanying increase in mitochondrial reactive oxygen species production, and resulted in decreased accumulation of markers of oxidative damage. PMID: 20435911
9. report that expression of Ndi1 in fly mitochondria leads to an increase in NADH-ubiquinone oxidoreductase activity, oxygen consumption, and ATP levels. PMID: 20089120
10. identify the ubiquinone binding site in Ndi1 PMID: 20192260
11. Disruption of NDI1 decreases ROS production and elongates the chronological life span of yeast, accompanied by the loss of survival fitness. PMID: 16436509
12. Oxidative stress was significantly decreased when the cells were transduced with NDI1. Furthermore, mitochondria from the NDI1-transduced cells showed a suppressed rate of ROS formation by the complex I inhibitors PMID: 17055488
13. data suggest that Ndi1 bears at least two distinct Q sites: one for bound Q and the other for catalytic Q. PMID: 17200125
14. NDI1 enzyme can improve the oxidative phosphorylation capacity in cells carrying the G11778A mutation and protect the cells from oxidative stress and cell death. PMID: 17320357

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KEGG: sce:YML120C

STRING: 4932.YML120C