Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans egl-3 Polyclonal antibody

Uniprot No.

G5ECN9

Target Names

egl-3

Alternative Names

egl-3 antibody; kpc-2 antibody; C51E3.7 antibody; Neuroendocrine convertase 2 antibody; NEC 2 antibody; EC 3.4.21.94 antibody; Egg-laying defective protein 3 antibody; Kex2-like prohormone convertase 2 antibody; CELPC2 antibody; Prohormone convertase 2 antibody; PC2 antibody; Proprotein convertase 2 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans egl-3 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. Cleaves pro-insulin-like proteins ins-3, ins-4 and ins-6 into their mature active forms. Together with convertase kpc-1, cleaves pro-insulin-like protein ins-18. By controlling ins-4 and ins-6 processing and thus the activation of the daf-2/InsR pathway, negatively modulates synapse development and synaptic transmission at neuromuscular junctions. Similarly, by controlling ins-4 and ins-6 processing, negatively regulates dauer formation under optimal environmental conditions. Under adverse environmental conditions, may promote dauer formation by processing ins-18, a daf-2/InsR antagonist. May cleave dense-core vesicle membrane protein ida-1. Involved in egg-laying, fat storage and locomotion.

Gene References into Functions

Role of PC2/EGL-3 in the processing of FMRFamide-like peptide (FLP) precursors and neuropeptide-like protein (NLP) precursors in nematodes. PMID: 16945111

Subcellular Location

Cell projection, axon. Cytoplasmic vesicle, secretory vesicle lumen. Secreted.

Protein Families

Peptidase S8 family, Furin subfamily

Tissue Specificity

Expressed in head and tail ganglia. Expressed in neurons including mechanosensory and motor neurons, and interneurons (at protein level). Expressed in the nerve ring, ventral nerve cord and intestine.

Database Links

KEGG: cel:CELE_C51E3.7

STRING: 6239.C51E3.7a

UniGene: Cel.18027

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egl-3 Antibody

Product Details

Customer Reviews and Q&A

Target Background