NOP3 Antibody

Code CSB-PA015921XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) NPL3 Polyclonal antibody
Uniprot No. Q01560
Target Names NPL3
Alternative Names NPL3 antibody; MTR13 antibody; MTS1 antibody; NAB1 antibody; NOP3 antibody; YDR432W antibody; D9461.19 antibody; Nucleolar protein 3 antibody; Mitochondrial targeting suppressor 1 protein antibody; Nuclear polyadenylated RNA-binding protein 1 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) NOP3 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function Required for pre-rRNA processing and nuclear import as well as mitochondrial protein targeting. Binds to poly(A).
Gene References into Functions
  1. Npl3 participates in DNA double-strand break resection by promoting the proper biogenesis of EXO1 mRNA. PMID: 28472517
  2. a model in which Hmt1, via arginine methylation of Npl3, facilitates U1 snRNP engagement with the pre-mRNA to promote usage of non-consensus splice sites by the splicing machinery. PMID: 28392442
  3. Npl3 binds diverse sites on large numbers of transcripts, and the loss of Npl3 results in transcriptional readthrough on many genes. PMID: 26694144
  4. An essential novel function for Npl3 in the cytoplasm, which supports monosome formation for translation initiation. PMID: 24100011
  5. yeast Npl3, the most abundant RNA-binding hnRNP, prevents R-loop-mediated genome instability PMID: 24240235
  6. our data reveal a connection between Npl3 and an extensive array of chromatin factors and describe an unanticipated functional link between histone H2B ubiquitination and pre-mRNA splicing PMID: 23209445
  7. Npl3 and Cbc2 may function in maintaining telomere stability perhaps as telomere capping proteins. PMID: 22902537
  8. These results support a model in which arginine methylation facilitates Npl3 export directly by weakening contacts with nuclear proteins. PMID: 15998636
  9. NPL1p can bind to nascent mRNAs, heat shock RNA was exported efficiently in temperature-sensitive NPl13 mutant strains PMID: 17259545
  10. The results support a model in which balanced competition of Npl3 with mRNA processing factors may promote recognition of proper polyadenylation sites while suppressing cryptic sites. PMID: 17684230
  11. Improved segmental isotope labeling methods for the NMR study of multidomain of of large proteins: application to the RRMs of NPL3. PMID: 17936301
  12. Structure of NPL3 protein and its interaction with mRNA 3'-end processing signals is reported. PMID: 18022637
  13. Proper levels of Npl3 protein are achieved by a negative feedback loop in which phosphorylated Npl3 suppresses efficient recognition of the productive processing signals in its own transcript. PMID: 18391019
  14. Npl3 has a role in RNA polymerase II elongation and its regulation by phosphorylation PMID: 18818768
  15. A single SR-like protein, Npl3, is required for efficient splicing of a large set of pre-mRNAs in Saccharomyces cerevisiae PMID: 19061647
  16. Nuclear localization of Npl3 also requires specific arginine-glycine (RG) sequences, yet heterologous RG domains allow similar modulation of Npl3 transport by arginine methylation. PMID: 19454603
  17. model in which Npl3p engenders translational fidelity by promoting the remodeling of mRNPs during translation termination PMID: 19733178

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Subcellular Location Nucleus, nucleolus
Protein Families RRM GAR family
Database Links

KEGG: sce:YDR432W

STRING: 4932.YDR432W


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