NPL3 Antibody

1. Npl3 participates in DNA double-strand break resection by promoting the proper biogenesis of EXO1 mRNA. PMID: 28472517
2. a model in which Hmt1, via arginine methylation of Npl3, facilitates U1 snRNP engagement with the pre-mRNA to promote usage of non-consensus splice sites by the splicing machinery. PMID: 28392442
3. Npl3 binds diverse sites on large numbers of transcripts, and the loss of Npl3 results in transcriptional readthrough on many genes. PMID: 26694144
4. An essential novel function for Npl3 in the cytoplasm, which supports monosome formation for translation initiation. PMID: 24100011
5. yeast Npl3, the most abundant RNA-binding hnRNP, prevents R-loop-mediated genome instability PMID: 24240235
6. our data reveal a connection between Npl3 and an extensive array of chromatin factors and describe an unanticipated functional link between histone H2B ubiquitination and pre-mRNA splicing PMID: 23209445
7. Npl3 and Cbc2 may function in maintaining telomere stability perhaps as telomere capping proteins. PMID: 22902537
8. These results support a model in which arginine methylation facilitates Npl3 export directly by weakening contacts with nuclear proteins. PMID: 15998636
9. NPL1p can bind to nascent mRNAs, heat shock RNA was exported efficiently in temperature-sensitive NPl13 mutant strains PMID: 17259545
10. The results support a model in which balanced competition of Npl3 with mRNA processing factors may promote recognition of proper polyadenylation sites while suppressing cryptic sites. PMID: 17684230
11. Improved segmental isotope labeling methods for the NMR study of multidomain of of large proteins: application to the RRMs of NPL3. PMID: 17936301
12. Structure of NPL3 protein and its interaction with mRNA 3'-end processing signals is reported. PMID: 18022637
13. Proper levels of Npl3 protein are achieved by a negative feedback loop in which phosphorylated Npl3 suppresses efficient recognition of the productive processing signals in its own transcript. PMID: 18391019
14. Npl3 has a role in RNA polymerase II elongation and its regulation by phosphorylation PMID: 18818768
15. A single SR-like protein, Npl3, is required for efficient splicing of a large set of pre-mRNAs in Saccharomyces cerevisiae PMID: 19061647
16. Nuclear localization of Npl3 also requires specific arginine-glycine (RG) sequences, yet heterologous RG domains allow similar modulation of Npl3 transport by arginine methylation. PMID: 19454603
17. model in which Npl3p engenders translational fidelity by promoting the remodeling of mRNPs during translation termination PMID: 19733178

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KEGG: sce:YDR432W

STRING: 4932.YDR432W