nth-1 Antibody

Code CSB-PA347471XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans nth-1 Polyclonal antibody
Uniprot No.
Target Names
nth-1
Alternative Names
nth-1 antibody; R10E4.5 antibody; Endonuclease III homolog antibody; CeNTH antibody; EC 3.2.2.- antibody; EC 4.2.99.18 antibody; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase antibody; DNA glycosylase/AP lyase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans nth-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Gene References into Functions
  1. we could detect no deficiency in base excision repair in the nth-1 strain. PMID: 22959841
  2. Data show that the protein encoded by the sequence containing both R10E4.5 and the 117-bp region upstream from it, and found that the protein had the NTH activity. PMID: 19481506
Subcellular Location
Nucleus. Mitochondrion.
Protein Families
Nth/MutY family
Database Links

KEGG: cel:CELE_R10E4.5

STRING: 6239.R10E4.5d

UniGene: Cel.10201

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