Nr2f6 Antibody

Datasheet
Code CSB-PA016058ZA01MO
Uniprot No. P43136
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Mouse Nuclear receptor subfamily 2 group F member 6 (Nr2f6) (1-390AA)
Raised in Rabbit
Species Reactivity Mus musculus
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2), Nr2f6, Ear-2 Ear2 Erbal2
Immunogen Species Mus musculus (Mouse)
Gene Names Nr2f6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Subcellular Location Nucleus
Protein Families Nuclear hormone receptor family, NR2 subfamily
Database Links

KEGG: mmu:13864

STRING: 10090.ENSMUSP00000002466

UniGene: Mm.28989

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