NR2F6

NR2F6, also known as nuclear receptor subfamily 2 group F member 6, is a nuclear receptor that plays a crucial role in immune regulation and tumor progression. Mechanistically, NR2F6 acts as a transcriptional repressor, modulating the expression of various genes involved in immune response and inflammation. It is associated with multiple signaling pathways, including NFAT/AP-1 and NF-κB, and has been implicated in diseases such as glioma and other cancers. Recent research suggests that NR2F6 may serve as a potential therapeutic target for cancer immunotherapy, with ongoing studies exploring its role in combination with checkpoint inhibitors and other anti-tumor agents.