oprI Antibody

Code CSB-PA319977XA01FQE
Size US$299
Image
  • Western Blot
    Positive WB detected in: recombinant protein
    All lanes: oprI Antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 40 kDa
    Observed band size: 40 kDa
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Product Details

Uniprot No.
Target Names
oprI
Alternative Names
Major outer membrane lipoprotein (Outer membrane lipoprotein I) oprI PA2853
Species Reactivity
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Immunogen
Recombinant Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprI protein (1-83aa)
Immunogen Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The process of generating polyclonal antibodies against oprI involves sequential immunizations of a rabbit with recombinant Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprI protein (1-83aa). Once an effective antibody titer is reached, the rabbit is bled, and antibodies are purified from the serum using affinity chromatography. Subsequent assessment of the oprI antibody's functionality in ELISA and WB applications confirms its specific reactivity towards Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprI protein.

The Pseudomonas aeruginosa oprI proteinin plays essential roles in the bacterium's biology and interactions with its environment. As a structural component of the outer membrane, oprI contributes to the integrity and stability of this protective barrier. OprI is implicated in the defense mechanisms of Pseudomonas aeruginosa, acting as part of the outer membrane's defense against antimicrobial agents, including host immune factors and antibiotics. Additionally, oprI may function as a virulence factor, influencing the pathogenicity of Pseudomonas aeruginosa by facilitating interactions with host tissues and contributing to immune evasion.

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Target Background

Gene References into Functions
  1. OprI on bacterial surfaces is responsible for the recruitment and susceptibility to amphipathic alpha-helical cationic antimicrobial peptides. PMID: 26248382
  2. Data show for the first time that OprI can modulate allergen-specific murine T helper 2 effector cells in an allergic response in vivo for a prolonged period via stimulation of the TLR2/4 signaling pathway. PMID: 15634935
Subcellular Location
Cell outer membrane; Lipid-anchor.
Database Links

KEGG: pae:PA2853

STRING: 208964.PA2853

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