OPT1 Antibody

Code CSB-PA334785XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OPT1 Polyclonal antibody
Uniprot No.
Target Names
OPT1
Alternative Names
OPT1 antibody; GSH11 antibody; HGT1 antibody; YJL212C antibody; HRD799 antibody; J0236 antibody; Oligopeptide transporter 1 antibody; High affinity glutathione transporter 1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OPT1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane.
Gene References into Functions
  1. Data suggest that protonated residues E/D135 or N710 in Hgt1p prevent substrate/glutathione from binding at high pH; mutation of these residues allows substrate/glutathione to bind in a proton-dependent manner through involvement of other residues. PMID: 28389436
  2. ScOPT1 and AtOPT4 are proton-coupled OPTs with broad but distinct substrate specificities and affinities. PMID: 16149917
  3. The cysteine-free Hgt1p was nonfunctional and pointed to a critical role being played by the native cysteine residues of Hgt1p. PMID: 19496824
  4. Asn-124 in transmembrane domain 1(TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop are essential for the transport activity of Hgt1. PMID: 19589778
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Oligopeptide OPT transporter family
Database Links

KEGG: sce:YJL212C

STRING: 4932.YJL212C

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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