Or22a Antibody

Code CSB-PA305699XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Or22a Polyclonal antibody
Uniprot No.
Target Names
Or22a
Alternative Names
Or22a; AN11; DOR22A.1; dor53; Or22A.1; CG12193; Odorant receptor 22a
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Or22a protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.
Gene References into Functions
  1. The or22a neuron major projected into glomerulus of DM2 and less projected to VC1 and VC31. PMID: 12555270
  2. odorant receptors thus form ligand-gated channels as well as complexes of odorant-sensing units and cyclic-nucleotide-activated non-selective cation channels PMID: 18408711
  3. signals by opening cation channels, through a mechanism that is largely independent of G proteins PMID: 18625400
  4. Data show that Or22a is expressed in approxiamately 25 olfactory sensory neurons and marks a small glomerulus, DM2. PMID: 18683641
  5. Intraspecific study of 4 natural populations of D melanogaster survey showed a copy-number polymorphism in some of the populations, with the 2 genes, Or22a & Or22b in the long variant and a single chimeric gene, Or22ab present in the short variant. PMID: 18922763

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Insect chemoreceptor superfamily, Heteromeric odorant receptor channel (TC 1.A.69) family, Or2a subfamily
Tissue Specificity
Expressed with Orco in 17-20 sensory neurons on the medial-proximal edge of the antenna. Expressed in the ab3A neuron which responds to ethyl butyrate.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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