YOS9 Antibody

Datasheet

Code	CSB-PA860329XA01SVG
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Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YOS9 Polyclonal antibody

Uniprot No.

Q99220

Target Names

YOS9

Alternative Names

YOS9 antibody; YDR057W antibody; D4222 antibody; Protein OS-9 homolog antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YOS9 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. The recognition of targets is N-glycan specific. Functions in recruiting misfolded protein substrates in conjunction with HRD3.

Gene References into Functions

Yos9p and Hrd1p mediate ER retention of misfolded proteins in the early stage of ERAD, which constitutes a process separable from the later degradation step. PMID: 22298424
Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex. PMID: 22262864
Data show that Yos9 slows the degradation of the unglycosylated ERAD substrate CPY *0000. PMID: 21871892
Yos9p has a previously unrecognized role in the quality control of nonglycosylated proteins PMID: 21737688
Data suggest that Yos9p plays a critical role in the bipartite recognition of terminally misfolded glycoproteins. PMID: 16168370
Data show that Yos9p binds directly to substrates to discriminate misfolded from folded proteins. PMID: 16168371
Data show that Yos9 protein in Saccharomyces cerevisiae is essential for efficient degradation of mutant glycoproteins. PMID: 16168372
Yos9p ensures that only terminally misfolded polypeptides are degraded. PMID: 16845381

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Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

Protein Families

OS-9 family

Database Links

KEGG: sce:YDR057W

STRING: 4932.YDR057W

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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YOS9 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background