otpb Antibody

Code CSB-PA732227XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) otpb Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
otpb antibody; otp antibody; otp1 antibody; otpa antibody; Homeobox protein orthopedia B antibody
Raised in
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) otpb protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum.
Gene References into Functions
  1. These findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete oxytocinergic hypothalamic circuit whose disrupted development affects social behavior. PMID: 28094761
  2. Identification of an evolutionarily conserved vertebrate OTP enhancer module with activity in a restricted area of the forebrain. PMID: 25427861
  3. These observations suggest that the requirement for otpa and otpb function during development of the larval diencephalon is partially redundant. PMID: 24073233
  4. Otp1 transcription factor is important for regulation of diencephalon development and early neuronal progenitors. PMID: 17074092
  5. Orthopedia is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system. PMID: 17481897
  6. Results describe the ontogeny of vasotocin-expressing cells in zebrafish, and the selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area. PMID: 18330923

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Subcellular Location
Protein Families
Paired homeobox family, Bicoid subfamily
Tissue Specificity
Isoform 1 and isoform 2 are expressed in brain and testis.
Database Links
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