Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PAN1 Polyclonal antibody

Uniprot No.

P32521

Target Names

PAN1

Alternative Names

PAN1 antibody; DIM2 antibody; MDP3 antibody; MIP3 antibody; YIR006C antibody; YIB6CActin cytoskeleton-regulatory complex protein PAN1 antibody; Mitochondrial distribution of proteins protein 3 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PAN1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.

Gene References into Functions

Thus Pan1 phosphorylation is part of a novel mechanism that regulates endocytic compartment interactions with each other and with actin cables. PMID: 26914139
A region of Pan1 spanning the second EH domain and central region was critical for viability and endocytosis. Other regions of Pan1 supported viability and not endocytosis, suggesting that Pan1 may have an additional role independent of endocytosis. PMID: 25631817
N-terminal part of Pan1's central coiled-coil region binds End3 C-terminus. PMID: 24118836
Pan1p, and possibly other components of the actin cytoskeleton, are necessary to properly regulate growth of dividing cells in response to the presence of some alternative carbon sources (oleate) in the medium. PMID: 16171804
Pan1p: an actin director of endocytosis in yeast. PMID: 17303466
Pan1 and the type I myosins interactions promote an actin activity important at a late stage in endocytic internalization. PMID: 17522383
Pan1 contains functional nuclear localization signals (NLS) and a NES and appears to shuttle in certain circumstances PMID: 17967424

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.

Protein Families

PAN1 family

Database Links

KEGG: sce:YIR006C

STRING: 4932.YIR006C

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PAN1 Antibody

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Target Background