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Recombinant Saccharomyces cerevisiae Actin cytoskeleton-regulatory complex protein PAN1 (PAN1), partial

Recombinant Saccharomyces cerevisiae Actin cytoskeleton-regulatory complex protein PAN1 (PAN1), partial

Code	CSB-YP333705SVG
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP333705SVG
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP333705SVG-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP333705SVG
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP333705SVG
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PAN1

Uniprot No.

P32521

Alternative Names

PAN1; DIM2; MDP3; MIP3; YIR006C; YIB6CActin cytoskeleton-regulatory complex protein PAN1; Mitochondrial distribution of proteins protein 3

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.

Gene References into Functions

Thus Pan1 phosphorylation is part of a novel mechanism that regulates endocytic compartment interactions with each other and with actin cables. PMID: 26914139
A region of Pan1 spanning the second EH domain and central region was critical for viability and endocytosis. Other regions of Pan1 supported viability and not endocytosis, suggesting that Pan1 may have an additional role independent of endocytosis. PMID: 25631817
N-terminal part of Pan1's central coiled-coil region binds End3 C-terminus. PMID: 24118836
Pan1p, and possibly other components of the actin cytoskeleton, are necessary to properly regulate growth of dividing cells in response to the presence of some alternative carbon sources (oleate) in the medium. PMID: 16171804
Pan1p: an actin director of endocytosis in yeast. PMID: 17303466
Pan1 and the type I myosins interactions promote an actin activity important at a late stage in endocytic internalization. PMID: 17522383
Pan1 contains functional nuclear localization signals (NLS) and a NES and appears to shuttle in certain circumstances PMID: 17967424

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.

Protein Families

PAN1 family

Database Links

KEGG: sce:YIR006C

STRING: 4932.YIR006C

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