par-6 Antibody

1. we find that vab-1 lies in the same genetic pathway as cdc-42 and is responsible for polarizing CDC-42 activity to the medial tip. Together, these data establish a previously uncharacterized role for polarized CDC-42, in conjunction with PAR-6, PAR-3 and an Eph receptor(vab-1), during epithelial intercalation. PMID: 27861585
2. the arcade cell epithelium polarizes by a PAR-6-mediated pathway that is independent of E-cadherin, beta-integrin and beta-laminin. PMID: 25773364
3. PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow. PMID: 22887994
4. evidence PAR polarity arises from coupling of advective transport by flowing cell cortex to a multistable PAR reaction-diffusion system; advection in active, flowing medium provides mechanism for mechanically templated pattern formation in development PMID: 22021673
5. Centrosomes localize apically by first moving toward lateral foci of the conserved polarity proteins PAR-3 and PAR-6, then move together with these foci toward the future apical surface. Embryos lacking PAR-3 fail to localize their centrosomes apically. PMID: 22425160
6. PAR-2 and PAR-6, which localize to opposing PAR domains, undergo exchange between well mixed cytoplasmic populations and laterally diffusing membrane-associated states PMID: 21518794
7. Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans PMID: 20122916
8. PAR proteins function in both apicobasal and anterior-posterior asymmetry during the first few cell cycles of embryogenesis. PMID: 13129846
9. CDC-37-mediated inhibition of the CDC-42-dependent binding site and PAR-3-mediated release of this inhibition provide a key mechanism for the anterior accumulation of PAR-6. PMID: 16943281
10. CDC-42 interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry. PMID: 16996049
11. PAR-6 is required for junction formation but not apicobasal polarization in C. elegans embryonic epithelial cells. PMID: 17314130
12. nos-3 loss of function mutant suppresses the lethality of par-2 mutants by regulating PAR-6 protein levels. PMID: 18502413
13. study identified a RhoGAP, PAC-1, which mediates embryo radial polarity & gastrulation by excluding PAR-6 from contacted cell surfaces; PAC-1 provides a dynamic molecular link between cell contacts & PAR proteins that polarizes embryos radially PMID: 18583611

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KEGG: cel:CELE_T26E3.3

STRING: 6239.T26E3.3a.3

UniGene: Cel.8562