ey Antibody

1. Loss of Ey within the peripodial epithelium leads to the loss of dpp expression within the eye, failure of the furrow to initiate, and abrogation of retinal development. These findings reveal an unexpected mechanism for how Pax6 controls eye development in Drosophila. PMID: 29980566
2. The loss of Pax6, but not of Eya, is required for Sfmbt dependent eye-to-wing transformation. PMID: 29530880
3. Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila. PMID: 28826476
4. Pax6 initiates both eye specification and proliferation PMID: 28584125
5. Eyeless (Ey), Drosophila homolog of Pax6, regulates the production of glial cells in the brain. PMID: 26670857
6. The third helix of the Ey HD can directly interact with the RED subdomain in Ey Paired domain. PMID: 25234589
7. Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation. PMID: 24886829
8. eyeless links neurogenesis and neuronal migration PMID: 21208993
9. B52/SRp55 makes 2 isoforms, the longer with a 60-AA alternative exon at the start of the paired domain & is defective for ectopic eye formation & target DNA binding. Overproduction causes small eyes. The shorter causes eye overgrowth & disorganization. PMID: 17327915
10. The direct functional antagonism between PB (proboscipedia) and EY proteins suggests a novel crosstalk mechanism integrating known selector functions in head morphogenesis. PMID: 12490563
11. eyeless controls eye specification together with several other genes (review) PMID: 15170856
12. Twin of eyeless (toy) directly regulates eyeless (ey), which is necessary for initiating the eye developmental pathway. PMID: 15253940
13. acts as a transcriptional activator, with DNA-binding specificity PMID: 15973436
14. Eyeless controls insulin-producing cells function by the direct transcriptional control of one of the major Dilps, dilp5 PMID: 18852455
15. Ey harbors transactivation domains within the CT segment Non-conserved NT & B segments of Ey have transcriptional repressive activity. Ey ability to be both activator & repressor lets it transform non-retinal tissues & induce ectopic eye formation. PMID: 19406113
16. Toy and Ey, to some extent, can substitute for each other. PMID: 19484263
17. New eyeless alleles, each with a single missense mutation in one of the four domains of the protein, in abnormal eye and brain development. PMID: 19666017

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KEGG: dme:Dmel_CG1464

STRING: 7227.FBpp0099810

UniGene: Dm.6503