Pde4a Antibody

Code CSB-PA261418XA01RA
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Pde4a Polyclonal antibody
Uniprot No. P54748
Target Names Pde4a
Alternative Names Pde4a antibody; cAMP-specific 3',5'-cyclic phosphodiesterase 4A antibody; EC antibody; DPDE2 antibody
Raised in Rabbit
Species Reactivity Rattus norvegicus (Rat)
Immunogen Recombinant Rattus norvegicus (Rat) Pde4a protein
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene References into Functions
  1. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. PMID: 23986500
  2. PDE4A upregulation during cholestatic liver injury plays a role in inflammation and fibrosis. PMID: 23887098
  3. beta-adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PMID: 23094097
  4. These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population. PMID: 21898905
  5. Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes. PMID: 18721873
  6. cGMP and cAMP phosphodiesterase PDE4 and AMPK/NOX2 have a role in early cardiac hypertrophy induced by angiotensin II PMID: 21151982
  7. results suggest that XAP2 functionally interacts with PDE4A5 in cells. PMID: 12810716
  8. The results indicate that phosphodiesterase-4 blockers are strong stimulants of the respiratory network. We hypothesize that these or related agents may be potent tools for a treatment of drug-induced disturbances of breathing in (preterm) infants. PMID: 16581183
  9. In addition to the brain, (R)-[11C]rolipram binds selectively to PDE4 across all cardiac regions, skeletal muscle, lungs and pancreas, but not in the adipose tissues. PMID: 17210463
  10. The effects of increased cyclic AMP and glucocorticoid dexamethasone administration on Brucella melitensis-induced lipid peroxidation, Brucella suppressed antioxidant enzyme activities and PDE4 transcripts in rats are reported. PMID: 17397885
  11. unique tissue distribution of PDE4A8, combined with the evolutionary divergence of its N-terminus, suggest that this isoform may have a specific function in regulating cAMP levels in human skeletal muscle and brain PMID: 18095939

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Subcellular Location Cytoplasm, perinuclear region.
Protein Families Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Tissue Specificity Isoform 2 is testis specific.
Database Links

KEGG: rno:25638

STRING: 10116.ENSRNOP00000057815

UniGene: Rn.91357

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