Pde4a Antibody

1. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. PMID: 23986500
2. PDE4A upregulation during cholestatic liver injury plays a role in inflammation and fibrosis. PMID: 23887098
3. beta-adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PMID: 23094097
4. These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population. PMID: 21898905
5. Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes. PMID: 18721873
6. cGMP and cAMP phosphodiesterase PDE4 and AMPK/NOX2 have a role in early cardiac hypertrophy induced by angiotensin II PMID: 21151982
7. results suggest that XAP2 functionally interacts with PDE4A5 in cells. PMID: 12810716
8. The results indicate that phosphodiesterase-4 blockers are strong stimulants of the respiratory network. We hypothesize that these or related agents may be potent tools for a treatment of drug-induced disturbances of breathing in (preterm) infants. PMID: 16581183
9. In addition to the brain, (R)-[11C]rolipram binds selectively to PDE4 across all cardiac regions, skeletal muscle, lungs and pancreas, but not in the adipose tissues. PMID: 17210463
10. The effects of increased cyclic AMP and glucocorticoid dexamethasone administration on Brucella melitensis-induced lipid peroxidation, Brucella suppressed antioxidant enzyme activities and PDE4 transcripts in rats are reported. PMID: 17397885
11. unique tissue distribution of PDE4A8, combined with the evolutionary divergence of its N-terminus, suggest that this isoform may have a specific function in regulating cAMP levels in human skeletal muscle and brain PMID: 18095939

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KEGG: rno:25638

STRING: 10116.ENSRNOP00000057815

UniGene: Rn.91357