Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDE7A Polyclonal antibody

Uniprot No.

Q13946

Target Names

PDE7A

Alternative Names

5''-cyclic phosphodiesterase 7A antibody; HCP 1 antibody; HCP1 antibody; High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A antibody; High affinity cAMP-specific 3'' antibody; P2A antibody; PDE 7 antibody; PDE 7A antibody; PDE1/PDE2 yeast human complement of antibody; PDE7 antibody; PDE71 antibody; PDE7A antibody; PDE7A_HUMAN antibody; Phosphodiesterase 7A antibody; Phosphodiesterase isozyme 7 antibody; Phosphodiesterase7A antibody; Rolipram insensitive phosphodiesterase type 7 antibody; TM 22 antibody; TM22 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) PDE7A protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Gene References into Functions

Low PDE7A expression is associated with sepsis. PMID: 28356347
PDE7A is a high-speed and low-affinity phosphodiesterase for cCMP. PMID: 25128584
PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood PMID: 23661015
PDE7 has the potential to regulate human T cell function including cytokine production, proliferation and expression of activation markers. PMID: 12067300
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells; PDE7A was expressed in neutrophils and alveolar macrophages PMID: 12388353
crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 & PDE7 PMID: 15994308
results show that specific gene silencing with the RNAi method is a useful tool for inhibiting the gene expression of specific PDEs and that PDE7 silencing upregulates several osteogenic genes and increases mineralization PMID: 18420479

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Subcellular Location

[Isoform PDE7A1]: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.; [Isoform PDE7A2]: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.

Protein Families

Cyclic nucleotide phosphodiesterase family, PDE7 subfamily

Tissue Specificity

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Database Links

HGNC: 8791

OMIM: 171885

KEGG: hsa:5150

STRING: 9606.ENSP00000385632

UniGene: Hs.527119

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PDE7A Antibody

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