PTC6 Antibody

Code CSB-PA333093XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PTC6 Polyclonal antibody
Uniprot No.
Target Names
PTC6
Alternative Names
PTC6 antibody; AUP1 antibody; PPP2 antibody; YCR079W antibody; YCR79C antibody; YCR79W antibody; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2 antibody; mitochondrial antibody; PDP 2 antibody; EC 3.1.3.16 antibody; EC 3.1.3.43 antibody; Autophagy-related protein phosphatase 1 antibody; Phosphatase two C protein 6 antibody; Protein phosphatase 2C homolog 6 antibody; PP2C-6 antibody; Protein phosphatase of PDH protein 2 antibody; Pyruvate dehydrogenase complex phosphatase 2 antibody; PDC phosphatase 2 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PTC6 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein phosphatase that shows typical type 2C protein phosphatase (PP2C) activity. Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. Required for efficient mitophagy in stationary phase cells.
Gene References into Functions
  1. Data suggest that Ptc6p is the primary pyruvate dehydrogenase phosphatase in S. cerevisiae; Ptc6p exhibits substrate specificity for additional phosphatases. PMID: 28539364
  2. S. cerevisiae PTC6 participates in the negative regulation of Slt2 phosphorylation and vacuole morphogenesis under cell wall stress conditions PMID: 25449759
  3. encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae and confers rapamycin-resistant function. PMID: 17002782
  4. Pkp2p (Ygl059wp) and Ppp2p (Ycr079wp), are engaged in the regulation of this complex by affecting the phosphorylation state of Pda1p. PMID: 18180296
  5. the function of Aup1 in mitophagy could be explained through its regulation of Rtg3-dependent transcription. PMID: 19840933

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Subcellular Location
Mitochondrion intermembrane space. Mitochondrion matrix.
Database Links

KEGG: sce:YCR079W

STRING: 4932.YCR079W

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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