Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PEX19 Polyclonal antibody

Uniprot No.

Q07418

Target Names

PEX19

Alternative Names

PEX19 antibody; PAS12 antibody; YDL065C antibody; D2528 antibody; Peroxisomal membrane protein import receptor PEX19 antibody; Peroxin-19 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PEX19 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer. Directs PEX17, a peripheral component of the peroxisomal matrix protein translocation machinery, to peroxisomes. Stabilizes VPS1, a protein required for peroxisomal fission, at the peroxisomal membrane. Also acts in conjunction with PEX3 in the formation of peroxisomes from preperoxisomal compartments at the endoplasmic reticulum during de novo peroxisome synthesis, probably via the import of additional PMPs.

Gene References into Functions

Pex19p interacts with the cargo-binding domain of Myo2p PMID: 22486971
The PEX19 protein enriches first at the Pex3 foci on the ER and then on the maturing peroxisomes. PMID: 16009135
Pex3p amino-terminal domain targets to a subdomain of the endoplasmic reticulum and initiates the formation of a preperoxisomal compartment for de novo peroxisome synthesis; peroxisome formation depends on the activity of the genes PEX14 and PEX19 PMID: 16087670
Pex19p acts as a chaperone to stabilize the association of Vps1p with peroxisomes and not as a receptor involved in targeting Vps1p to peroxisomes PMID: 16520372
Pex19p has a role in targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery PMID: 16679311
Farnesylation of Pex19 is not needed for its function in peroxisome biogenesis in S. cerevisiae. PMID: 16791427
model that Pex19p is a cellular transporter for localization of tombusvirus p33 replication protein to the host peroxisomal membranes PMID: 18684480
The complete pool of Pex19p is processed by farnesyltransferase in vivo and that this modification is independent of peroxisome induction or the Pex19p membrane anchor Pex3p. PMID: 19451657

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Subcellular Location

Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane.

Protein Families

Peroxin-19 family

Database Links

KEGG: sce:YDL065C

STRING: 4932.YDL065C

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PEX19 Antibody

Product Details

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Target Background