pak-1 Antibody

Datasheet

Code	CSB-PA619143XA01CXY
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes:pak-1 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/20000 dilution Predicted band size: 38.3 kDa Observed band size: 38 kDa Exposure time: 10s.
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans pak-1 Polyclonal antibody

Uniprot No.

Q17850

Target Names

pak-1

Alternative Names

Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1) pak-1 C09B8.7

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans pak-1 protein (293-572aa )

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation. May phosphorylate mlc-4.

Gene References into Functions

FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms. PMID: 23994474
PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan. PMID: 23524941
Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression. PMID: 23019370
only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases. PMID: 19023419

Subcellular Location

Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, axon. Perikaryon.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Tissue Specificity

Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, seve

Database Links

KEGG: cel:CELE_C09B8.7

STRING: 6239.C09B8.7a.2

UniGene: Cel.17920

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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pak-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background