lov-1 Antibody

Code CSB-PA600254XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans lov-1 Polyclonal antibody
Uniprot No.
Target Names
lov-1
Alternative Names
lov-1 antibody; pkd-1 antibody; ZK945.9/ZK945.10 antibody; Location of vulva defective 1 antibody; Polycystic kidney disease 1 protein homolog antibody; Polycystin-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans lov-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2.
Gene References into Functions
  1. expressed in male-specific neurons, required for mating PMID: 26702651
  2. These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex. PMID: 17581863
  3. lov-1 is required for two male sensory behaviors: response and vulva location. It is a close homolog of human PKD1 and is localized in the same neurons as worm PKD-2, suggesting a common pathway. PMID: 10517638
Subcellular Location
Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=localizes to both the ciliary base and cilium proper.
Protein Families
Polycystin family
Tissue Specificity
Exclusively expressed in a subset of three categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons.
Database Links

KEGG: cel:CELE_ZK945.9

STRING: 6239.ZK945.9

UniGene: Cel.36423

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