plxna3 Antibody

Datasheet

Code	CSB-PA018219XA01DIL
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Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) plxna3 Polyclonal antibody

Uniprot No.

B0S5N4

Target Names

plxna3

Alternative Names

plxna3 antibody; si:dkey-7i23.3 antibody; Plexin A3 antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) plxna3 protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene References into Functions

\Homodimerization of PlxnA3 caused by mutation M1281L remains in the presence of ligand semaphorin 3F and co-receptor neuropilin-2a. PMID: 25565389
Data show that null mutants of the guidance receptor plexin A3 display motor axon branching defects. PMID: 23349787
in vivo demonstration of the intersection of spontaneous electrical activity with the PlexinA3 guidance molecule receptor in regulation of axon pathfinding PMID: 23302694
study shows plexinA3 is a crucial receptor for axon guidance cues in primary motor neurons PMID: 17475806
Plexin A3 plays an additional role in motor axonal morphogenesis. PMID: 17699603
Plxna3 acts with its ligand Sema3a1 for fasciculation and correct target selection of the Vp and VII motor axons. PMID: 17699608

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Plexin family

Tissue Specificity

Detected in primary motor neurons in the embryonic nervous system.

Database Links

KEGG: dre:567422

STRING: 7955.ENSDARP00000043999

UniGene: Dr.80739

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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plxna3 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background