pnr Antibody

Code CSB-PA347094XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) pnr Polyclonal antibody
Uniprot No.
Target Names
pnr
Alternative Names
pnr antibody; GATA-A antibody; CG3978 antibody; GATA-binding factor A antibody; Protein pannier antibody; Transcription factor GATA-A antibody; dGATA-A antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) pnr protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.
Gene References into Functions
  1. pnr appears to be highly regulated by Dpp and Brk on both the DV and AP axes during embryo patterning. PMID: 22513375
  2. Stat and Pnr represent two essential factors controlling blood cell maturation in the developing lymph gland and exert their functions both in a cell-autonomous and non-cell-autonomous manner. PMID: 21295568
  3. Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye PMID: 20691679
  4. manipulation of pannier activity in either germ layer affects cardiac specification, suggesting that its function is required in both the mesoderm and the ectoderm PMID: 12756184
  5. Pnr is positevely regulated by Tou during neuronal development. PMID: 16141224
  6. show that the dual function of pnr during regulation of wingless is achieved by one isoform repressing expression of the morphogen in the dorsal-most region of the disc while the other laterally promotes activation of the notal wingless expression PMID: 18042352
  7. Pnr is essential for early cardiac progenitor formation and also plays an important role in maintaining proper heart function. PMID: 19494035

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Subcellular Location
Nucleus.
Database Links

KEGG: dme:Dmel_CG3978

STRING: 7227.FBpp0082675

UniGene: Dm.7432

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