pnt Antibody

1. results demonstrate that PntP1 prevents both the premature differentiation and the dedifferentiation of INPs by regulating the expression of distinct target genes at different stages of imINP development. PMID: 27510969
2. Both PntP1 and PntP2 are required for oenocyte specification. Since PntP1 is a downstream effector of EGF signaling, these findings provide insight into how a Hox factor can both trigger and potentiate the EGF signal to promote an essential cell fate along the body plan. PMID: 28715417
3. PntP2 transcription factor plays a role in air sac development by regulation of the EGF ligand Vein protein. PMID: 26632449
4. Specific disruption of either pntP1 or pntP2 resulted in the same R8-only phenotype, demonstrating that both Pnt isoforms are essential for photoreceptor recruitment PMID: 23757412
5. Demonstrate that the Pointed-P2 PNT domain contains a dynamic N-terminal helix H0 appended to a core conserved five-helix bundle diagnostic of the SAM domain fold. PMID: 22936607
6. The MAPK/ERK pathway acts via the ETS-1 transcription factor Pointed. This mechanism permits physiological adjustment of insulin sensitivity and subsequent maintenance of circulating glucose at appropriate levels. PMID: 22242005
7. Pointed directly regulates the transcription of string and thereby cell proliferation PMID: 12447387
8. In different types of glial cells, REPO can act alone, or cooperate with either TTK69 or PNTP1 to regulate different target genes. PMID: 12702656
9. Data show that pannier acts upstream of pointed P2 in a developmental pathway in which pannier promotes cardiac mesoderm formation, and pointed acts subsequently to distinguish between cardioblast and pericardial cell fates. PMID: 12756183

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KEGG: dme:Dmel_CG17077

STRING: 7227.FBpp0088658

UniGene: Dm.2370