Pp1-87B Antibody

Code CSB-PA318305XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Pp1-87B Polyclonal antibody
Uniprot No.
Target Names
Pp1-87B
Alternative Names
Pp1-87B antibody; CG5650 antibody; Serine/threonine-protein phosphatase alpha-2 isoform antibody; EC 3.1.3.16 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Pp1-87B protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase.
Gene References into Functions
  1. Ectopic expression of dRif1 causes enlarged larval imaginal discs and early pupal lethality which is completely reversed by co-expression of PP1 87B, the major protein phosphatase in Drosophila, indicating genetic and functional interaction PMID: 26022086
  2. these findings shed light on the in vivo role of the PNUTS-PP1 holoenzyme and its contribution to the control of gene expression during early Drosophila development. PMID: 24204300
  3. PP1-87B has a role in coupling moesin-dependent cell shape changes to mitotic exit. PMID: 22209527
  4. PP1c not only binds TRX, but is a physiologically relevant regulator of TRX function in vivo. PMID: 12524522
Subcellular Location
Cytoplasm.
Protein Families
PPP phosphatase family, PP-1 subfamily
Database Links

KEGG: dme:Dmel_CG5650

STRING: 7227.FBpp0082067

UniGene: Dm.1623

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