PPH3 Antibody

1. Physical interaction between Pph3 and Mec1, mediated by cofactors Psy2 and Ddc2, is important for regulating the checkpoint response in yeast. PMID: 25533186
2. Data indicate that the phosphatase complex Pph3/Psy2 connects homologous end-joining (NHEJ) repair to cell cycle progression. PMID: 24498054
3. Data show that Pph3-Psy2 targets the glucose signal transducer protein Mth1, which is required for the dephosphorylation of Rgt1 upon glucose withdrawal, a critical event in the repression of HXT genes, which encode glucose transporters. PMID: 24277933
4. a three-protein complex (HTP-C, for histone H2A phosphatase complex) containing the phosphatase Pph3 that regulates the phosphorylation status of gammaH2AX in vivo and efficiently dephosphorylates gammaH2AX in vitro PMID: 16299494
5. Mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin, double mutants exhibit a synergistic response. PMID: 16322523
6. Rad53 regulates replication fork restart and initiation of late firing origins independently PMID: 17517611
7. Mutational analyses of conserved regions of Tap42/alpha4 identified a region critical for its interactions with PP2Ac. We propose a scaffolding function for Tap42/alpha4 whereby the interaction of PP2Ac promotes the dephosphorylation of substrates. PMID: 17616149
8. Results suggest that the trimeric Pph3p-Psy4p-Psy2p complex may dephosphorylate both gammaH2AX and Rad53p. PMID: 18647348

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KEGG: sce:YDR075W

STRING: 4932.YDR075W