pk Antibody

Datasheet

Code	CSB-PA381174XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) pk Polyclonal antibody

Uniprot No.

A1Z6W3

Target Names

Alternative Names

pk antibody; CG11084 antibody; Protein prickle antibody; Protein spiny legs antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) pk protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.

Gene References into Functions

We find that the E3 ubiquitin ligase complex Cullin1(Cul1)/SkpA/Supernumerary limbs(Slimb) regulates the stability of one of the peripheral membrane components, Prickle (Pk). PMID: 25996914
Pk and Sple form different complexes with distinct subcellular localizations in the eye and wing. PMID: 24998533
Fat and Core planar cell polarity (PCP) pathways patterns change during morphogenesis, undergoing phases of coupling and uncoupling that are regulated by antagonistic Core PCP protein isoforms Prickle and Spiny-legs. PMID: 25201685
These data reveal a previously unidentified pathway in the pathophysiology of seizure disorders and provide evidence for a more generalized cellular mechanism whereby Prickle mediates polarity by influencing microtubule-mediated transport. PMID: 25024231
Alternative Prickle (Pk-Sple) protein isoforms control the polarity of microtubule network. PMID: 25005476
Pk mediates feedback amplification to generate asymmetric planar cell polarity signaling in Drosophila. PMID: 12015986
Prickle localization is influenced by Strabismus function. PMID: 12642492
the initial membrane association of Diego depends on Fz, and that Diego physically interacts with Strabismus and Pk through its Ankyrin repeats PMID: 15306567
Prickle competitively binds with Dishevelled and thereby modulating Frizzled/Dishevelled activity. PMID: 15937478
Pk(Pk) is sufficient to mediate the intercellular feedback signalling. Significantly, Pk(Pk) but not Pk(Sple) is required for hexagonal cell packing in the pupal wing. PMID: 19028485
analysis of structural and membrane binding properties of the prickle PET domain PMID: 19053268

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Prickle / espinas / testin family

Tissue Specificity

Expressed in the wing, leg and eye imaginal disks. Expressed within the photoreceptors of the eye.

Database Links

KEGG: dme:Dmel_CG11084

STRING: 7227.FBpp0088115

UniGene: Dm.3470

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pk Antibody

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