PRP43 Antibody

1. These data indicate that the U2 snRNP-intron interaction is Prp43's major target. PMID: 27115347
2. Using Prp43 F357A mutants or pyrimidine nucleotides, we show that the lack of stacking of the nucleotide base to the F-motif decouples the NTPase and helicase activities of Prp43. In contrast the R159A mutant (R-motif) showed reduced ATPase and helicase activities. PMID: 28180308
3. Study shows the crystal structure of Prp43p bound to single-stranded poly-uracil RNA and reveals differences with viral ATPases in the RecA1 domain but with striking similarities with viral ATPases in the RecA2 domain of the catalytic core, including both a prominent beta-hairpin that bookends the 5' end of the RNA stack and a dynamic motif Va that is implicated in mediating translocation. PMID: 28416566
4. Results show that Prp43 expression is regulated by Cmg1 which stimulates its RNA helicase activity. PMID: 26821976
5. Prp43 differentially interacts with g-patch domains in Spp382, Sqs1, and Pxr1 G. PMID: 25808954
6. This study investigated the activation of Prp43 by Ntr1 in the presence and absence of RNA substrate. PMID: 24165877
7. The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. PMID: 20705241
8. Prp43p promotes the discard of suboptimal and optimal 5' exon and lariat intermediates indiscriminately. PMID: 20463285
9. Data report that cleavage of pre-rRNA at the 3'-end of 18 S rRNA, requires functional interactions between Nob1 and Prp43, and the cofactor Pfa1. PMID: 19801658
10. stimulation of ATPase/helicase activities of Prp43p by Pfa1p is required for efficient 20S pre-rRNA-to-18S rRNA conversion PMID: 19927118
11. The ATPase activity of Prp43p is required for early steps of pre-rRNA processing and normal accumulation of mature rRNAs. PMID: 16227579
12. Prp43p promotes recycling of snoRNAs and biogenesis factors during pre-rRNA processing. The dual function for Prp43p in the cell raises the possibility that ribosome biogenesis and pre-mRNA splicing may be coordinately regulated. PMID: 16382143
13. Its essential function is in its newly characterized role in ribosome biogenesis of both ribosomal subunits, positioning Prp43p to regulate both pre-mRNA splicing and ribosome biogenesis. PMID: 16382144
14. We report that Prp43 hydrolyzes all common NTPs and dNTPs and unwinds short 5'/3' tailed RNA/DNA duplexes in an ATP-dependent fashion. PMID: 16700561
15. Prp43 acts on preribosomal regions surrounding each binding site, with distinct functions at different locations. PMID: 19941819

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KEGG: sce:YGL120C

STRING: 4932.YGL120C