ptf1a Antibody

1. Results highlight the possibility that Ptf1a may act as an important transcription factor for enteric neuron development. PMID: 26865080
2. In ptf1a haploinsufficiency, more ptf1a-lineage-labeled cells are traced into the pancreatic Notch-responsive cell and endocrine compartments. More reduction of ptf1a gene dosage converts pancreatic progenitor cells to non-pancreatic cell fates. PMID: 25773748
3. Autoregulation of ptf1a is absolutely required for exocrine pancreas formation. PMID: 23876428
4. Postembryonic antagonism of Ptf1a, a master regulator of pancreatic development and acinar cell fate specification, induced expression of endocrine genes including insulin in the exocrine compartment. Induced insulin+ cells are derived from acinar cells. PMID: 21497092
5. The timing of Ptf1a expression suggests that it is involved in the very early stages or steps in the differentiation of amacrine cells, which can be seen to rapidly diversify into a large number of subtypes. PMID: 19732413
6. mapping, analysis of embryonic expression and role in pancreas development PMID: 15031114
7. Ptf1 function is inhibited by notch PMID: 15280211
8. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate. PMID: 18519637
9. Exocrine differentiation and proliferation factor (exdpf) is a direct target gene of pancreas-specific transcription factor 1a (Ptf1a). PMID: 19067490

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KEGG: dre:368662

STRING: 7955.ENSDARP00000011265

UniGene: Dr.86563