pygo Antibody

1. results are consistent with the idea that pygo functions independently of canonical Wnt signaling in the differentiation of the adult interchamber cardiac valves PMID: 24265259
2. humanized fly Pygo derepresses Notch targets, implying an inherent Notch-related function of classical Pygo orthologs, disabled in fly Pygo, which thus appears dedicated to Wnt signaling. PMID: 24183574
3. Double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional arrhythmia compared with pygo knockdown alone, suggesting that some of the effects of pygo are mediated by Ca2+ signaling. PMID: 24046329
4. nuclear component of the Wnt signalling pathway; presence of a PHD domain implicates Pygo protein in a chromatin-related function PMID: 11988739
5. nuclear PHD-finger protein required for Wingless signaling in Drosophila. PMID: 12015286
6. identifed conserved residues within Pygopus that are required for binding to Legless in vitro and for their activity in development PMID: 14612447
7. Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. PMID: 16005293
8. Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). PMID: 18498752
9. Pygo predisposes Drosophila T cell factor target genes for rapid Wingless-induced transcription, or it protects them against premature shut-down PMID: 19036929
10. the PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 PMID: 19493659

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KEGG: dme:Dmel_CG11518

STRING: 7227.FBpp0085167

UniGene: Dm.5270