Pdk4 Antibody

1. In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD. PMID: 29128353
2. our results suggest that PDK2/4 can be a potential target for the development of pharmacotherapy for the treatment of acute inflammatory pain PMID: 26931482
3. Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cancers PMID: 28692044
4. PDK4 mediates cisplatin-induced acute kidney injury. PMID: 28040265
5. Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 in the heart. FoxO1 directly regulates Pdk4 transcription in the heart, thereby controlling PDH activity and subsequent glucose oxidation rates. PMID: 28687587
6. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
7. FXR may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch. PMID: 26728993
8. Taken together, our results suggest that LPS induces PDK4 expression and alters glucose metabolism via the JNK pathway. PMID: 26740179
9. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification. PMID: 26560812
10. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy. PMID: 26769971
11. These findings reveal that there are divergent roles of PDKs during oocyte maturation and indicate a new mechanism controlling meiotic structure. PMID: 25991547
12. Double-knockout mice with global deletion of PDK2 and PDK4, which results in constitutively activated pyruvate dehydrogenase, preferentially oxidize glucose in muscle. PMID: 25368185
13. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
14. Diminished insulin signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice. PMID: 24116221
15. The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown. Hepatic Pdk4 may be critically involved in the pathogenesis of diabetes. PMID: 23940800
16. These results suggest a role for PDK4 in regulating the PDH complex in muscle and promoting gluconeogenic precursor recirculation during recovery from exhaustive exercise. PMID: 24305065
17. loss of both Pdk2 and Pdk4 attenuated HSC quiescence, glycolysis, and transplantation capacity. PMID: 23290136
18. Deletion of PDK4 prevented Angiotensin II-induced diastolic dysfunction and normalized glucose oxidation to basal levels. PMID: 23396452
19. the role of IL-6 signalling in adipose tissue during exercise PMID: 22844518
20. Data suggest that up-regulation of cardiac PDK4 by high-fat diet (HFD) occurs in conjunction with time-dependent activation of E2F1 transcription factor (E2F1); HFD may initiate early cardiac metabolic alterations through cyclin D1/E2F1/PDK4 axis. PMID: 22569253
21. PDK4 plays a role in reducing pyruvate dehydrogenase complex activation during low to moderate-intensity muscle stimulation, and that absence of PDK4 and the subsequent changes in carbohydrate utilization may alter force production. PMID: 22196220
22. These findings indicate that Pdk4 plays an important role in bone loss at unloading by promoting osteoclastogenesis. PMID: 21803180
23. PDK4 is a novel pivotal factor in adaptation to chemical stress. PMID: 21182459
24. upregulation of PDK4 in skeletal muscle PMID: 12099888
25. activation of FXR may suppress glycolysis and enhance oxidation of fatty acids via inactivation of the pyruvate dehydrogenase complex by increasing PDK4 expression PMID: 15721319
26. PGC-1alpha expression in skeletal muscle coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4), a negative regulator of glucose oxidation. PMID: 16314495
27. Pyruvate dehydrogenase kinase 4-deficient mice have lower fasting blood glucose levels, slightly improved glucose tolerance, and slightly greater insulin sensitivity compared with wild-type mice. PMID: 18430968
28. PDK4 upregulation in adipocytes participates in the hypolipidemic effect of thiazolidinediones through modulation of glyceroneogenesis PMID: 18519799
29. Regulation of the PDK4 isozyme by the Rb-E2F1 complex PMID: 18667418
30. PDHK4 deficiency creates conditions that alter upstream signalling components involved in the regulation of lipid metabolism. PMID: 19627255
31. The activation of pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha PMID: 11554740

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KEGG: mmu:27273

STRING: 10090.ENSMUSP00000019721

UniGene: Mm.235547