RAD18 Antibody

1. The Pol30-K196 residue plays a critical role in budding yeast DNA post-replication repair through interaction with Rad18. PMID: 27707542
2. following UV-induced damage, reactivation of Rad18, even after prolonged G2 arrest, restores viability and genome integrity. PMID: 23382077
3. The results imply that sumoylated PCNA is the physiological ubiquitylation target of budding yeast Rad18. PMID: 23034805
4. In this study we showed that DNA damage induced by hydrogen peroxide at the same mutagen doses causes significantly more mutations and lethal events in the rad18 mutant cells compared to control wild-type cells PMID: 22730775
5. Rad17, a subunit of the PCNA-like 9-1-1 checkpoint clamp is ubiquitylated; however, in contrast to previous results, modification of Rad17 is found to be independent of DNA damage, the Rad6-Rad18 complex. PMID: 20550940
6. Rad6-Rad18 and Ubc13-Mms2-Rad5 act sequentially and mediate proliferating cell nuclear antigen poly-ubiquitylation by stepwise addition of ubiquitin monomers. PMID: 19851286
7. role in polyubiquitination of PCNA PMID: 15507115
8. error-free component of the RAD6/RAD18 pathway completes replication by a mechanism employing recombination between partially replicated sister strands, possibly by means of transient template strand switching or copy choice. PMID: 16247017
9. Study suggests that Rad18/Rad5/Mms2 and Mgs1 are required to promote replication when forks are destabilized or stalled due to defects in Pol delta. PMID: 16949354
10. Rad6-Rad18 promotes DNA-damage-dependent transcriptional induction as well as checkpoint functions by catalyzing monoubiquitination at the K197 residue of the Rad17 subunit of the 9-1-1 complex. PMID: 18485869
11. The interactions between Rad18, RPA and DNA and discuss their contribution to the activation of DNA damage bypass, was examined. PMID: 19029798
12. key role for the RAD6-RAD18-RAD5 error-free postreplication repair (RAD6 error-free PRR) pathway in promoting cell growth and survival, in response to chronic low-dose ultraviolet light PMID: 19079240
13. Rad18 is required for the formation of X-shaped sister chromatid junctions (SCJs) at damaged replication forks through a process involving PCNA polyubiquitylation and the ubiquitin-conjugating enzymes Mms2 and Ubc13 PMID: 19092928

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KEGG: sce:YCR066W

STRING: 4932.YCR066W