RAD5 Antibody

1. By analyzing the formation of Rad5 foci after MMS treatment, we showed that some specific DNA structures rather than mono-ubiquitination of proliferating cell nuclear antigen are required for the recruitment of Rad5 to the damaged site PMID: 29396601
2. Rad5 Ub-ligase and ATPase/helicase activities are required for the response to DNA damage. PMID: 25310987
3. Data indicate that the DNA helicase Rad5 ubiquitin ligase activity does not require ATP. PMID: 25690888
4. Findings suggest a structural role of the helicase domain of Rad5 and the helicase activity is dispensable for error-free lesion bypass. PMID: 24674630
5. A survey of various yeast deletion mutants converged on the Rad5 pathway of DNA damage tolerance by template switching as the likely target pathway of NSC109268 in mediating cellular sensitization to cisplatin. PMID: 24130896
6. Rad5 stably interacts with Rev1 via the N-terminal region of Rad5 and the C-terminal region of Rev1. PMID: 23142547
7. we genetically characterized a conserved yeast ICL repair pathway composed of the yeast homologs (Mph1, Chl1, Mhf1, Mhf2) of four FA proteins (FANCM, FANCJ, MHF1, MHF2 PMID: 22696213
8. The authors demonstrate that in the absence of PCNA SUMOylation, Mms2-Ubc13 and Rad5 may, independently of each other, function in the stimulation of translesion DNA synthesis. PMID: 21362066
9. Results indicate that multiple activities of Rad5 function coordinately with homologous recombination factors to enable replication template switch events that join sister chromatids at stalled forks and bypass DNA damage. PMID: 20541998
10. RAD5 contributes to DNA double-strand break repair via the Mre11/Rad50/Xrs2 protein complex. PMID: 16224103
11. In contrast to the role of Rad5 in postreplicational repair, however, where its function is coupled with that of Mms2-Ubc13, Rad5 function in translesion synthesis would be largely independent of this ubiquitin-conjugating enzyme complex PMID: 16908531
12. Data show that yeast Rad5 has a DNA helicase activity that is specialized for replication fork regression. PMID: 17936713
13. Rad5 is required for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiae PMID: 18757916
14. Rad5 acts both to align monoUb-PCNA with Ub-charged Ubc13 and to stimulate Ub transfer onto Lys(63) of a Ub acceptor. PMID: 19706603

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KEGG: sce:YLR032W

STRING: 4932.YLR032W