prfC Antibody

1. Data show that peptide chain release factor RF-3 (RF3) hydrolyzes GTP and dissociates from the ribosome before peptide chain release factor RF-1 (RF1)dissociation. PMID: 27779391
2. Together, these data define a more precise role for RF3 in translation termination and provide insights into the function of this family of translational GTPases PMID: 24667215
3. Ordering of critical elements of switch loop I and the P loop, which help to form the GTPase catalytic site, are caused by interactions between the G domain of RF3. PMID: 22187675
4. Data suggest how RF3, by stabilizing the hybrid state of the ribosome, facilitates the dissociation of class I release factors. PMID: 21903932
5. Study examines the role of RF3 in the bacterial cell and show that the deletion of this gene sensitizes cells to other perturbations that reduce the overall fidelity of protein synthesis. PMID: 22000017
6. Data show a novel class of RF3 mutations specifically defective in the tRNA drop-off reaction, and these mutations suggest differential molecular pathways closely related to the guanine nucleotide modes of RF3. PMID: 20043913
7. The data show that RF3*GTP binding induces large conformational changes in the ribosome, which break the interactions of the class I RF with both the decoding center and the GTPase-associated center leading to the release of the class I RF. PMID: 17540173

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KEGG: ecj:JW5873

STRING: 316385.ECDH10B_4532