Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans rho-1 Polyclonal antibody

Uniprot No.

Q22038

Target Names

rho-1

Alternative Names

rho-1 antibody; rhoa antibody; Y51H4A.3 antibody; Ras-like GTP-binding protein rhoA antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans rho-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity.

Gene References into Functions

Here, the authors report that in the Caenorhabditis elegans zygote, feedback between active RhoA and myosin induces a contractile instability in the actomyosin cell cortex. PMID: 28117665
RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans. PMID: 21387015
Presynaptic changes in Rho activity at Caenorhabditis elegans neuromuscular junctions can radically change animal behavior via modulation of two separate pathways affecting a neurotransmitter release PMID: 16391233
RHO-1 activity is required to facilitate the segregation of CDC-42 and PAR-6 to the anterior. PMID: 16899536
The upstream GPA-12/RHGF-1 pathway stimulates only a subset of RHO-1 downstream effectors, suggesting that either the RHO-1 effectors require different levels of activated RHO-1 or there are two distinct pools of RHO-1 within C. elegans neurons. PMID: 17139250

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Protein Families

Small GTPase superfamily, Rho family

Tissue Specificity

In larvae and adults, enriched at the tip of the head where the anterior sensory organ is located and in the pharyngeal nerve ring (at protein level). In embryos, enriched at the boundaries of dorsal cells undergoing intercalation, ventral enclosure and e

Database Links

KEGG: cel:CELE_Y51H4A.3

STRING: 6239.Y51H4A.3

UniGene: Cel.17449

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rho-1 Antibody

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