Rrm2 Antibody

1. mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites PMID: 25838540
2. R2 expression may discriminate cervical cancer phenotype and radiochemotherapy outcome PMID: 23552804
3. Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression. PMID: 21275172
4. Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus. PMID: 22403396
5. exclusion as candidate congenital polycystic kidney gene PMID: 11701955
6. illegitimate recombination initiated by c-Myc PMID: 11840336
7. Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src and Erk Map Kinases. PMID: 11900481
8. Cobalt substitution of mouse R2 ribonucleotide reductase as a model for the reactive diferrous state. PMID: 12087093
9. The small subunit R2 of murine ribonucleotide reductase (RR) may be important for nuclear RR activity and for RR activity in cells having abnormally low ATP levels, such as cancer cells. PMID: 12578384
10. S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region PMID: 14688249
11. x-ray crystallographic analysis of the native dinuclear iron center of ribonucleotide reductase protein R2 PMID: 15322079
12. Results, supported by molecular modeling, strongly suggest that Arg265 of ribonucleotide reductase R2 is involved in the proton-coupled electron transfer pathway and may act as a proton mediator during catalysis. PMID: 16829694
13. Chk1 is required for DNA replication at least through regulating RNR2 gene transcription. PMID: 18616928
14. results indicate that the affinity of the RNR R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins PMID: 19492792
15. The structure of the active site of ribonucleotide reductase M2 (PDB 1XSM) in the radical state (tyrosyl radical) was studied using EPR. PMID: 19639135

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KEGG: mmu:20135

STRING: 10090.ENSMUSP00000020980

UniGene: Mm.471826